C3orf67 is the former symbol for the human gene now approved by HGNC as CFAP20DC. The name C3orf67 stands for chromosome 3 open reading frame 67, a placeholder-style name used before a more specific approved symbol was assigned.
The gene is protein-coding, but its biological role is still not well described in general reference databases. It is mainly useful as a genome annotation entry unless a specific study is discussing it.
Nomenclature
HGNC lists CFAP20DC as the approved symbol and records C3orf67 as a previous symbol. Gene names can change when nomenclature committees update symbols to better reflect gene families, predicted domains, or new information.
Because older articles, datasets, and search tools may still use C3orf67, both names can appear in scientific databases. When comparing sources, it is important to check identifiers rather than relying only on the text symbol.
Location and Identifiers
Ensembl lists CFAP20DC on chromosome 3 on the reverse strand. GeneCards, UniProt, Ensembl, and HGNC connect the entry with identifiers such as HGNC:24763, Ensembl ENSG00000163689, and UniProt Q6ZVT6.
These identifiers are useful because the symbol C3orf67 may be confused with similarly named open reading frame genes on other chromosomes.
Protein Product
UniProt describes the associated human protein as an uncharacterised protein with the imported gene name CFAP20DC and the synonym C3orf67. The older open reading frame name suggests that the original annotation identified a potential protein-coding region before the function was clear.
At present, broad public databases do not present a settled, simple biological function for the protein. Any claim about disease relevance, pathway role, or molecular function should be tied to a specific study or database entry.
Research Context
Open reading frame genes often begin as predicted coding regions found through genome sequencing and annotation. Some later receive detailed functional names when experiments clarify their role. Others remain lightly studied for long periods.
C3orf67 is best handled carefully in wiki text. It should not be presented as a well-characterised disease gene unless the claim is supported by current genetic evidence.
References
Discussion log
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