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'''CEP70''' is a human protein-coding gene associated with centrosomes and microtubule organisation. It encodes centrosomal protein of 70 kDa, a protein studied for its role in microtubule assembly, centrosome localisation, and mitotic spindle organisation.
	'''CEP70''' is the official symbol for '''centrosomal protein 70''', a human protein-coding gene. It is also listed under the synonym '''BITE'''. The gene is associated with centrosome and microtubule biology.

CEP70 is a specialist cell-biology topic. It should not be treated as a well-established diagnostic marker for ordinary clinical use unless a specific claim is backed by a strong biomedical source.
	Centrosomes are major microtubule-organising centres in human cells. They help control cell shape, intracellular transport and the formation of the mitotic spindle during cell division.

== Gene and Protein ==	== Gene and Protein ==
UniProt lists the reviewed human CEP70 protein entry as centrosomal protein of 70 kDa. The protein is associated with the centrosome, a cellular structure that helps organise microtubules.
	NCBI Gene lists human CEP70 as Gene ID 80321. Ensembl identifies the gene as ENSG00000114107 on chromosome 3. UniProt lists the reviewed human protein entry as Q8NHQ1, centrosomal protein of 70 kDa.

Microtubules are part of the cytoskeleton. They help cells maintain shape, move material internally, and organise chromosomes during cell division. Centrosomal proteins such as CEP70 are studied because errors in centrosome and spindle behaviour can affect cell division.
	The encoded protein is reported at protein level in UniProt and the Human Protein Atlas. Like many centrosomal proteins, CEP70 is mainly discussed in relation to cell structure, microtubule organisation and mitosis.

== Function ==
UniProt describes CEP70 as playing a role in the organisation of both existing and newly forming microtubules in interphase cells. During mitosis, it is required for the organisation and orientation of the mitotic spindle.
	== Cellular Role ==
	UniProt describes CEP70 as playing a role in the organisation of both existing and new microtubules in interphase cells. During mitosis, it is required for the organisation and orientation of the mitotic spindle.

Experimental work has reported that Cep70 localises to the centrosome throughout the cell cycle and interacts with gamma-tubulin. That interaction helps explain how the protein is recruited to the centrosome and why it is connected to spindle assembly.
	Laboratory research has reported that CEP70 localises to the centrosome throughout the cell cycle and interacts with gamma-tubulin. That interaction is relevant because gamma-tubulin is a key centrosomal component involved in microtubule nucleation.

== Microtubule Assembly ==
Research on Cep70 has linked the protein to microtubule assembly. PubMed-indexed studies report that Cep70 can promote microtubule assembly in vitro and is involved in microtubule organisation in mammalian cells.
	== Centrosomes and Microtubules ==
	Microtubules form part of the cell's cytoskeleton. They support cell shape, intracellular movement and chromosome separation during cell division.

This does not mean that CEP70 alone controls cell division. Centrosome function depends on many proteins, and CEP70 is one part of a wider system.
	The Human Protein Atlas describes the centrosome as the main microtubule-organising centre in human cells. During cell division, centrosome function is important for correct spindle formation and the separation of sister chromatids.

== Expression ==
The Human Protein Atlas includes CEP70 expression data across tissues and cell types. Such expression resources are useful for research, but expression alone does not prove that a gene causes a disease or is a useful clinical test.
	== Expression and Data Resources ==
	Public gene databases provide different kinds of CEP70 information:

== Research and Disease Context ==
Some studies have examined CEP70 in cancer biology, paclitaxel sensitivity, angiogenesis, cilia-related biology, and male fertility models. These topics remain research areas rather than simple clinical conclusions.
	* NCBI Gene gives identifiers, genomic context and links to sequences and publications.
	* UniProt summarises protein function, sequence, subcellular information and evidence.
	* The Human Protein Atlas summarises protein evidence, tissue data and subcellular data.
	* Ensembl gives genome location, transcript models and cross-references.

A cautious summary is that CEP70 is biologically relevant to centrosome and microtubule processes. Strong disease claims should name the study, model system, and evidence level.
	These resources are useful because many small gene pages can otherwise overstate what is known from limited experimental work.

	== Clinical Research ==
	CEP70 is mainly a cell-biology gene in public reference databases. Some research has examined possible links between CEP70 variation and reproductive biology, including male infertility, but the gene is not usually presented as a routine diagnostic topic in general medical sources.

	Claims about disease involvement should therefore be tied to specific studies or curated gene-disease databases rather than stated as established clinical fact.

== See Also ==	== See Also ==
	* [[Centrosome]]
* [[Chromosome_3]]	* [[Chromosome_3]]
* [[Cell_Biology]]
* [[Microtubule]]	* [[Microtubule]]
* [[Mitosis]]
	* [[Cell_Division]]

== References ==	== References ==
* [https://www.uniprot.org/uniprotkb/Q8NHQ1/entry UniProt: CEP70 human protein entry]
	* [https://www.ncbi.nlm.nih.gov/datasets/gene/80321/ NCBI Gene: CEP70]
	* [https://www.uniprot.org/uniprotkb/Q8NHQ1/entry UniProt: CEP70 human]
* [https://www.proteinatlas.org/ENSG00000114107-CEP70 Human Protein Atlas: CEP70]	* [https://www.proteinatlas.org/ENSG00000114107-CEP70 Human Protein Atlas: CEP70]
* [https://pubmed.ncbi.nlm.nih.gov/21795687/ PubMed: CEP70 protein interacts with gamma-tubulin]
* [https://pubmed.ncbi.nlm.nih.gov/22427462/ PubMed: Cep70 promotes microtubule assembly in vitro]
* [https://pubmed.ncbi.nlm.nih.gov/28632150/ PubMed: centrosomal protein 70 as a mediator of paclitaxel sensitivity]
* [https://pubmed.ncbi.nlm.nih.gov/33285087/ PubMed: role for Cep70 in centriole amplification in multiciliated cells]
	* [https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000114107 Ensembl: CEP70]
	* [https://pubmed.ncbi.nlm.nih.gov/21795687/ PubMed: CEP70 protein and gamma-tubulin]

	[[Category:Biology]]
[[Category:Genes]]	[[Category:Genes]]
[[Category:Cell biology]]
[[Category:Human proteins]]